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Faculty: Dr. Dave Benson

Recent Publications

Undergraduate student names appear in bold.

(24 publications, 1039 citations. Independent Work: 12 publications, 100 citations).

Shete, V., Benson D.E. “Linking Metalloprotein Design with Semiconductor Nanoparticles for Imaging Pb2+ Ion Speciation in Red Blood Cells”, Biochemistry, 48, 2009; 462-470.

Swain, M.D., Octain, J., Benson, D.E.  “Unimolecular, Soluble Semiconductor Nanoparticle-Based Biosensors for Thrombin Using Charge/Electron Transfer.” Bioconjugate Chem., 19, 2008; 2520-2526.

Trisler, K., Looger, L.L., Sharma, V., Baker, M., Benson, D.E., Trauger, S., Schultz, P.G., Smider, V.V. “A Metalloantibody That Irreversibly Binds a Protein Antigen” J. Biol. Chem., 282, 2007; 26344-26353.

Aryal, B.P., Benson, D.E. “Polyhistidine Fusion Proteins Can Nucleate the Growth of CdSe Nanoparticles”, Bioconjugate Chem., 18, 2007; 585-589

Aryal, B.P., Benson, D.E. “Electron Donor Solvent Effects Provide Semiconducting Nanoparticle-based Biosensors”, J. Am. Chem. Soc., 128, 2006; 15986-15987.

Benson, D.E. “Reagentless Biosensors Based on Nanoparticles” in Volume 8, “Nanomaterals for Biosensing” in the Nanomaterials for Life Sciences book series, Wiley Interscience, 2006; 337-367.

Aryal, B.P., Sandros, M.G., Neupane, K.P., Benson, D.E. “Metallothioneins Initiate Semiconducting Nanoparticle Cellular Toxicity”, Small, 2, 2006; 1159-1163.

Sandros, M.G., Shete, V., Benson, D.E. “Selective, Reversible, Reagentless Maltose Biosensing with Core-Shell Semiconducting Nanoparticles” Analyst, 131, 2006; 229 - 235.

Sandros, M.G., Gao, D., Benson, D.E. “A Modular Nanoparticle-Based System for Reagentless Small Molecule Biosensing.” J. Am. Chem. Soc. 127, 2005; 12198-12199.

Shaw, J.L., Yee, G.T., Wang, G., Benson, D.E., Gokdemir, C., Ziegler, C.J.  “Magneto-Structural Relationships in a Series of Dinuclear Oxalato-Bridged (Diphenyldipyrazolylmethane)copper(II) Complexes.” Inorg. Chem. 44, 2005, 5060-5067.

Sandros, M.G., Gao, D., Gokdemir, C., Benson, D.E., “General, High-Affinity Approach for the Synthesis of Fluorophore Appended Protein Nanoparticle Assemblies.” Chem. Commun. 2005; 2832-2834.

Swain, M.D., Benson, D.E. “Geometric preferences of crosslinked protein-derived cofactors reveal a high propensity for near-sequence pairs.” Proteins: Struct. Funct. Bioinform 59, 2005; 64-71.

Publications from work prior to independent appointment:

Dattelbaum, J.D., Looger, L.L., Benson, D.E., Sali, K.M., Thompson, R.B., Hellinga, H.W. “Analysis of Allosteric Signal Transduction Mechanisms in an Engineered Fluorescent Maltose Biosensor.” Protein Sci. 14, 2005; 284-291.

Bioelectronic sensors and methods of using same in analyte detection. Hellinga, H.W., Conrad, D.W., Benson, D.E. Duke University, USA; PCT Int. Appl., 2003; 38 pp.

Benson, D.E., Haddy, A.E., Hellinga, H.W. “Converting a Maltose Receptor into a Binuclear Copper Oxygenase by Computational Design” Biochemistry 41, 2002; 3262-3269.

Unno, M., Christian, J.F., Sjodin, T., Benson, D.E., Macdonald IDG, Sligar SG, Champion PM.  “Complex formation of cytochrome P450(cam) with putidaredoxin - Evidence for protein-specific interactions involving the proximal thiolate ligand” J. Biol. Chem., 277, 2002; 2547-2553.

Benson, D.E., Conrad, D.W., de Lorimier, R.M., Trammell, S.A., Hellinga, H.W. “Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins” Science 293, 2001; 1641-1644.

Trammell, S.A., Goldston, H.M., Tran, P.T., Tender, L.M., Conrad, D.W., Benson, D.E., Hellinga, H.W. “Synthesis and Characterization of a Ruthenium(II)-Based Redox Conjugate for Reagentless Biosensing” Bioconjugate Chem. 12, 2001; 643-647.

Benson, D.E, Wisz, M.S., Hellinga, H.W. “Rational Design of Nascent Metalloenzymes” Proc. Natl. Acad. Sci. 97, 2000; 6292-6297.

Schlichting, I., Berendzen, J., Chu, K., Stock, A.M., Maves, S.A., Benson, D.E., Sweet, B.M., Ringe, D., Petsko, G.A., Sligar SG. “The catalytic pathway of cytochrome P450cam at atomic resolution” Science 287, 2000; 1615-1622.

Benson, D.E, Wisz, M.S., Hellinga, H.W. “The development of new biotechnologies using metalloprotein design” Curr. Opin. Biotech. 9, 1998; 370-376.

Benson, D.E., Wisz, M.S., Liu, W.T., Hellinga, H.W. “Construction of a novel redox protein by rational design: Conversion of a disulfide bridge into a mononuclear iron-sulfur center” Biochemistry 37, 1998; 7070-7076.

Unno, M., Christian, J.F., Benson, D.E., Gerber, N.C., Sligar SG, Champion PM. “Resonance Raman investigations of cytochrome P450(cam) complexed with putidaredoxin” J. Am. Chem. Soc. 119, 1997; 6614-6620.

Benson, D.E., Suslick, K.S., Sligar SG. “Reduced oxy intermediate observed in D251N cytochrome P450cam” Biochemistry 36, 1997; 5104-5107.


Minor in Biochemistry

Minor in Chemistry


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