Jennifer Jewett VanAntwerp

Calvin College · Engineering Department · 1726 Knollcrest Circle SE · Grand Rapids, MI  49546

jjvanant@calvin.edu  ·  Phone: (616) 526-8581  ·  Fax: (616) 526-6501

Education:

Ph.D., Chemical Engineering                                                                                     1999

University of Illinois at Urbana-Champaign (GPA = 4.0/4.0)

Thesis:  Affinity Maturation of the D1.3 Antibody Using Yeast Surface Display and Flow Cytometry

Advisor:  Dr. K. Dane Wittrup

 

M.S., Chemical Engineering                                                                                      1997

University of Illinois at Urbana-Champaign (GPA = 4.0/4.0)

Thesis:  Thermodynamic Characterization of Affinity Maturation: Entropic Changes Exhibited in a Higher Affinity Mutant of the D1.3 Antibody

Advisor:  Dr. K. Dane Wittrup

 

B.S., Chemical Engineering                                                                                                  1994

Michigan State University, East Lansing, MI (GPA = 3.98/4.00)

work experience:

Calvin College                                                                           Grand Rapids, Michigan

Assistant Professor, Engineering Department                                                1999-present

·         ENGR 101: Introduction to Engineering Design

·         ENGR 102: Engineering Communications, Analysis, and Design

·         ENGR 106: Engineering Chemistry and Materials Science

·         ENGR 319: Introduction to Thermal/Fluid Sciences

·         ENGR 335: Mass Transfer and Separations

·         IDIS 110: Research and Information Technology

 

Consulting                                                                                      Grand Rapids, Michigan

Chemical Engineering                                                                                                          2002-2003

Evaluate and implement new sampling system for pilot plant (Pfizer, Inc., Holland, Michigan). Supervise student assistants.

 

Pfizer, Inc.                                                                                             Holland, Michigan

Professional Intern, Chemical Development Group                                     Summer, 2000

·         Feasibility study of biotransformations for synthesis of pharmaceuticals.

 

University of Illinois                                                                                  Urbana, Illinois

Research Assistant, Department of Chemical Engineering                                1994-1999

·         Research Area:  Protein Engineering (for higher affinity antibodies)

·         Techniques:  Creation and screening of protein libraries for directed evolution of protein properties, Production and purification of proteins, Yeast surface display, Flow cytometry (fluorescence activated cell sorting), Isothermal titration calorimetry, Fluorescence spectroscopy, Molecular biology.

·         Supervised four undergraduate students conducting biochemical engineering research related to my thesis.

 

University of Illinois                                                                                  Urbana, Illinois

Teaching Assistant, Department of Chemical Engineering                                 1995-1997

·         Introduction to Chemical Engineering (CHE 261), Chemical Engineering Thermodynamics (CHE 370), Chemical Engineering Laboratory (CHE 374), Special Topics - Biochemical Engineering (CHE 396).

 

Amway Corporation                                                                                    Ada, Michigan

Engineering Intern, Process Research and Development Dept.                  Summer 1993

·         Tested the ULTRAMAX process optimization software by designing and conducting experiments, for both the pilot plant and production line, to increase the bulk density of powdered laundry detergent.

·         Wrote a manual to aid effective use of the software for future process development.

 

IBM                                                                                                     Burlington, Vermont

Engineering Intern                                                                                           Summer 1992

·         Designed and conducted experiments to improve the process for fabrication of lithography masks, including work in Class I Clean Room environment.

 

Michigan State University                                                          East Lansing, Michigan

Undergraduate Research Assistant, Dept. of Chemical Engineering                 1990-1992

·         Conducted experiments in liquid-liquid separations, using a hydrocyclone separator.

·         Wrote protocols for lab techniques.

peer- reviewed Publications:

B.A. Kellogg, J.J. VanAntwerp, K.D. Wittrup (in preparation). A survey of methods to affinity mature antibody fragments using targeted saturation mutagenesis.

 

J.J. VanAntwerp, J. VanAntwerp, D.A. Vander Griend, W.W. Wentzheimer (2004). Chemistry and materials science for all engineering disciplines: A novel interdisciplinary team-teaching approach. Proceedings of the 2004 American Society for Engineering Education (ASEE) Conference, Salt Lake City, Utah, June, 2004.

W.W. Wentzheimer, G.E. Ermer, J.J. VanAntwerp, S.H. VanderLeest, An optimal engineering education: The BSE at a Liberal Arts college. Proceedings of the 2004 American Society for Engineering Education (ASEE) Conference, Salt Lake City, Utah, June, 2004.

J.J. VanAntwerp and K.D. Wittrup (2000).  Fine affinity discrimination by yeast surface display and flow cytometry.  Biotechnology Progress, 16: 31-37.

E.V. Shusta, J.J. VanAntwerp, and K.D. Wittrup (1999).  Biosynthetic polypeptide libraries.   Current Opinion in Biotechnology, 10: 117-122.

J.J. VanAntwerp and K.D. Wittrup (1998).  Thermodynamic characterization of affinity maturation: the D1.3 antibody and a higher affinity mutant.  Journal of Molecular Recognition, 11: 10-13.

OTHER Publications:

P. Schonewill, E. Smith, J. VanAntwerp, J.J. VanAntwerp, B. VandenBosch, J. Vliem, W.W. Wentzheimer. Alternative sampling – Project summary and recommendations. November 2003.

J.J. VanAntwerp. Feasibility study of biotransformation for Gabapentin synthesis. Final Report for Internship, Pfizer Internal Document. August 9, 2000.

J.J. VanAntwerp. Regioselectivity during biotransformations for Gabapentin synthesis. Pfizer Internal Document. July 28, 2000.

J.J. VanAntwerp. Increasing yields from biotransformations for Gabapentin synthesis. Pfizer Internal Document. July 7, 2000.

Presentations:

J.J. VanAntwerp, J. VanAntwerp, D.A. Vander Griend, W.W. Wentzheimer (2004). Chemistry and Materials Science for All Engineering Disciplines: A Novel Interdisciplinary Team-Teaching Approach. Proceedings of the 2004 American Society for Engineering Education (ASEE) Conference, Salt Lake City, Utah, June, 2004.

J.J. VanAntwerp. Biotransformations: Let Bacteria Do the Dirty Work. Pfizer Chemical Development Group, Internal Presentation. August 9, 2000.

J.J. VanAntwerp and K.D. Wittrup: Osmotic stress and affinity maturation by yeast surface display.  American Institute of Chemical Engineers Annual Meeting, Miami, FL, November 1998.

K.S. Midelfort, E.T. Boder, M.C. Kieke, E.V. Shusta, J.J. VanAntwerp, D.M. Kranz and K.D. Wittrup: Directed evolution of protein binding, stability, and expression properties by yeast surface display.  Molecular Interaction Technologies ’98, San Francisco, CA, October 1998 (poster).

J.J. VanAntwerp, E.T. Boder and K.D. Wittrup: Antibody engineering by yeast surface display.  216th American Chemical Society National Meeting, Boston, MA, August 1998.

J.J. VanAntwerp and K.D. Wittrup: The role of osmotic stress in the affinity maturation of the D1.3 antibody by yeast surface display.  The Whitaker Foundation Annual Meeting, La Jolla, CA, August 1998 (poster).

J.J. VanAntwerp and K.D. Wittrup: Thermodynamic characterization of affinity maturation: the D1.3 antibody and a higher affinity mutant.  11th Annual Gibbs Conference on Biothermodynamics, Carbondale, IL, October 1997.

J.J. VanAntwerp and K.D. Wittrup: Thermodynamic characterization of antibody and higher mutant binding to antigen.  12th International Symposium on Affinity Interactions: Fundamentals and Applications of Biomolecular Recognition, Kalmar, Sweden, June 1997 (poster).

J.J. VanAntwerp and K.D. Wittrup Thermodynamic characterization of the D1.3 antibody and a mutant: the role of bound water molecules.  American Institute of Chemical Engineers Annual Meeting, Chicago, IL November 1996 (poster).

GRANTS:

J. VanAntwerp, J.J. VanAntwerp, W.W. Wentzheimer (2001). Alternative sampling methods/sites for pilot plant scale reactors. Chemical Development, Pfizer Inc. (Holland, MI). Amount awarded: $99,600.

 

PROFESSIONAL DEVELOPMENT ACTIVITIES:

·         American Society for Engineering Education Annual Meeting, Salt Lake City, UT, 2004.

·         Christian Engineering Education Conference, Salt Lake City, Utah, 2004.

·         Exceed Teaching Workshop, American Society of Mechanical Engineers, Santa Clara, CA, 2004.

·         J. Pieper Reading Group with the Dean of the Chapel, Calvin College, 2003.

·         American Institute of Chemical Engineers Annual Meeting, Indianapolis, Indiana, 2002.

·         “How a Reformed Christian Perspective Can Inform Biotechnology and Biotechnology-Related Policy,” Working Group, Calvin Center for Christian Scholarship, 2001-2002.

·         Symposium on Synthetic Organic Chemistry, Hope College, Holland, Michigan, 2000.

·         Graduate Teaching Certification, Univ. of Illinois Office of Instructional Resources, 1999.

·         Instructor for University of Illinois All-Campus Teaching Assistant Orientation, 1998.

·         "Effective Teaching: A Workshop," taught by R. Felder and R. Brent, and sponsored by the Academy for Excellence in Engineering Education at the University of Illinois, 1998.

·         Completed one-semester course, University of Illinois Dept. of Educational Organization and Leadership, "Teaching in the College and University Setting," 1995.

 

Professional Service:

·         Reviewer for:

o        American Society for Engineering Education Conference, 2005.

o        Textbook (Emergence and Evolution of Novel Designs), Wiley, 2004.

o        Christian Engineering Education Conference, 2004.

·         “Careers in Chemical Engineering” visits to high school classes, 2000-present.

·         Calvin College “Engineering Explorations” program for middle school students, 2003.

 

INSTITUTional Service:

·         Calvin College Student Life Committee, 2003-present.

·         Calvin College Student Discipline Committee, 2000-2003.

·         Calvin College Mentoring Program, 2000-present.

·         Calvin Academy for Lifelong Learning (CALL) Class Instructor, 2005.

·         Calvin College Chapel Speaker, 1999.

·         Engineering Department Meetings – Recorder of Minutes, 2003-2004.

·         Engineering Department Seminar Coordinator, 2004-present.

·         Faculty Advisor to Calvin Women Scientists, 2005-present.

·         Faculty Advisor to Society of Women Engineers Interest Group, 2001-2002.

·         Mentor for Calvin College Discovery Club Fellowship Pre-college program, 2005.

selected honors and awards:

·         Outstanding Teaching Award, U. of Illinois College of Liberal Arts and Sciences, 1997.

·         University of Illinois List of Teachers Ranked as Excellent by their Students, 1997.

·         Whitaker Foundation Graduate Fellowship in Biomedical Engineering, 1995-1999.

·         National Defense Science and Engineering Graduate Fellowship, 1994-1995.

·         National Science Foundation Graduate Research Fellowship, declined, 1994.

·         The Honor Society of Phi Kappa Phi - National Graduate Fellowship, 1994-1995.

·         American Institute of Chemical Engineers National Student Design Competition, Honorable Mention Award, 1994.