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Faculty: Dr. Kumar Sinniah

Recent Publications & Published Abstracts

Undergraduate student names appear in bold.                        

Nicole Michmerhuizen, Christine Timmer, Margaret Van Winkle, Kylin Hamann, and Kumar Sinniah, "Characterizing the Biomolecular Interactions between Insulin and G-Quadruplex DNA", Biophys. J. 104, 2013, 419a.

Abigail Leistra, Amanda Witte, Seok Ki Choi, and Kumar Sinniah, "An Atomic Force Microscopy Study of Riboflavin Receptor Targeting Nanoparticles", Biophys. J. 104, 2013, 556a-557a.

Amanda Witte, Christine Timmer, JJ. Gam, S.K. Choi, M.M. Banaszak Holl,B.G. Orr, J.R. Baker Jr., K. Sinniah, "Biophysical Characterization of a Riboflavin-Conjugated Dendrimer Platform for Targeted Drug Delivery", Biomacromolecules 13, 2012; 507−516.

R.K. Haynes, K.W. Cheu, H.W. Chan, H.N. Wong, K.Y. Li, M.M. Tang, M.J. Cheng, Z.F. Guo, Z.H. Guo, Kumar Sinniah, Amanda Witte, P.Coghi, D. Monti, "Interactions between artemisinins and other anti-malarial drugs in relation to the cofactor model - a unifying proposal for drug action", ChemMedChem 12, 2012, 2204-2226.

Amanda Witte, Christine Timmer, Jeremy Gam, Seok Ki Choi, and Kumar Sinniah, "Characterizing a Riboflavin-Dendrimer Platform for Targeted Drug Delivery Applications", Biophys. J. 102, 2012, 66a.

Christine Timmer, Amanda Witte, Niecia Flikweert, and Kumar Sinniah, "Characterizing the Binding of G-Quadruplex DNA to Insulin by Single Molecule and Bulk Ensemble Methods", Biophys. J. 102, 2012, 75a.

Anna Plantinga, Amanda Witte, Ming-Hsin Li, Andrew Harmon,* Seok Ki Choi, Mark M. Banaszak Holl, Brad G.Orr, James R. Baker, Jr., and Kumar Sinniah, "Bioanalytical screening of riboflavin antagonists for targeted drug delivery - A kinetic and thermodynamic study", ACS Med. Chem. Lett. 2, 2011; 363-367.

Anna Plantinga, Amanda Witte, Seok-Ki Choi, and Kumar Sinniah, "Characterizing riboflavin antagonists for targeted drug delivery", Biophys. J. 100, 2011; S1: 553a.

Christine Timmer and Kumar Sinniah, "Investigating the binding of insulin to G-quadruplex DNA by differential scanning calorimetry", Biophys. J. 100, 2011; S1: 231a.

Kumar Sinniah, Susanna Lynch, Heather Baker, Sarah Byker, Dejian Zhou, "A single molecule study of Guanine Quadruplex DNA" Biophys. J. 98, 2010; S1: 592a.

Susanna Lynch, Rachel Battershell, Jordan Scott, Dejian Zhou, and Kumar Sinniah, "A single molecule force spectroscopy study of the binding interaction between insulin and G-quadruplex DNA" Biophys. J. 98, 2010; S1: 592a.

L. Devon Triplett, Daniel Q. McNerny, J. Gabriel Grodzicki, Kumar Sinniah, Mark M. Banaszak Holl, Bradford G. Orr, "Investigating the interaction between folic acid and folate binding protein at the single molecule level", Biophys. J. 98, 2010; S1: 596a.

Susanna Lynch, Heather Baker, Sarah Byker, Dejian Zhou, and Kumar Sinniah, "Single molecule force spectroscopy on G-quadruplex DNA," Chem. Euro. J. 15, 2009; 8113-8116.

Susanna Lynch, Heather Baker, Sarah Byker, Dejian Zhou, and Kumar Sinniah, "Single Molecule Force Spectroscopy of Guanine Quadruplex DNA," Biophys. J. 96, 2009, 36a.

Kumar Sinniah, Laura Porter-Peden, Sarah Byker, Ronald Blankespoor, Dejian Zhou, Chris Abell, and Trevor Rayment, "A Single Molecule Study of Enzyme-Inhibitor Interactions," Biophys. J. 96, 2009;643a.

Laura Porter-Peden, Sarah Kamper, Mark Vander Wal, Ronald Blankespoor, and Kumar Sinniah, "Estimating kinetic and thermodynamic parameters from single molecule enzyme inhibitor interactions", Langmuir 24, 2008; 11556-11561.

Jennifer Nichols, Joey Buthker, and Kumar Sinniah, "The Effect of Divalent Cations (Mg2+, Zn2+, Mn2+, and Ca2+) on the Hybridization Efficiency Of DNA,"  Biophys. J. 94, 2008; 1712.

Sarah Kamper, Laura Porter-Peden, Ronald Blankespoor, Mark Vander Wal, and Kumar Sinniah, "The Effect of Tether Length in Single Molecule Force Spectroscopy," Biophys. J. 94, 2008; 1714.

Laura Porter-Peden, Sarah Kamper, Kumar Sinniah, Ronald Blankespoor, Dejian Zhou, Chris Abell, and Trevor Rayment, "Kinetics and Thermodynamics of Enzyme-Inhibitor Interactions," Biophys. J. 94, 2008; 1720.

Sarah Kamper, Laura Porter-Peden, Ronald Blankespoor, Kumar Sinniah, Dejian Zhou, Chris Abell, and Trevor Rayment, "Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single molecule force spectroscopy", Langmuir 23, 2007; 12561-12565.

Xiuzhu Wang, Dejian Zhou, Kumar Sinniah, Caroline Clarke, Louis Birch, H. Li, Trevor Rayment, Chris Abell, "Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy", Langmuir 22, 2006; 887-892.

Mark Vander Wal, Sarah Kamper, Jennifer Headley, and Kumar Sinniah, "Effect of contact force and salt concentration on the unbinding of a DNA duplex by force spectroscopy", Langmuir 22, 2006; 882-886 .

Dejian Zhou, Kumar Sinniah, Chris Abell, and Trevor Rayment, "Label-free detection of DNA hybridization at the nanoscale: An AFM based highly sensitive and selective method", Angewandte Chemie International Edition 42, 2003; 4934-4937.

Kimberly Aumann, Karen C. J. Muyskens, and Kumar Sinniah, "Visualizing Atoms, Molecules, and Surfaces by Scanning Probe Microscopy", J. Chem. Educ. 80, 2003; 187.

Dejian Zhou, Kumar Sinniah, Chris Abell and Trevor Rayment, "The Use of Atomic Force Microscopy for Making Addresses in DNA Coatings", Langmuir 18, 2002; 8278.

Jamie Paauw, John Ubels, and Kumar Sinniah, "Investigating Live Fixed Chang Conjunctival and Corneal Fibroblast Cells by Atomic Force Microscopy", Current Eye Research 25, 2002; 61.

Mark Schotanus, Kimberly Aumann, and Kumar Sinniah, "Using Force Spectroscopy to Investigate the Binding of Complementary DNA in the Presence of Intercalating Agents", Langmuir 18, 2002; 5333-5336.

Kumar Sinniah and Kenneth Piers, "Ion Chromatography: Analysis of Ions in Pond Waters", J. Chem. Educ. 78, 2001; 358.

Steve Robey and Kumar Sinniah, "Initial etching of GaAs (001) during hydrogen plasma etching" Journal of Applied Physics 88, 2000; 2994.

Kumar Sinniah, Adam B. Steel, Cary J. Miller, and Janice E. Reutt-Robey, "Solvent Exclusion and Chemical Contrast in Scanning Force Microscopy," J. Am. Chem. Soc. 37, 1996; 892.

Kumar Sinniah, Cary J. Miller, and Janice E. Reutt-Robey, "Chemical Contrast in Scanning Force Microscopy," Bull. Amer. Phys. Soc. 41, 1996; 9.

Kumar Sinniah, Jun Chen, Janice E. Reutt-Robey, and Cary J. Miller "Self-Assembled w -Hydroxyalkyl thiol Monolayers with Internal Functionalities: Electrochemical and Infrared Structural Characterization of Ether-containing Monolayers," J. Phys. Chem . 99, 1995; 14500.

Kumar Sinniah, Janice E. Reutt-Robey, Anita R. Brown, and Doug J. Doren, "Kinetics of Step-Site Filling for CO/Ni(9,1,1): A Pulsed Molecular-Beam-Surface Infrared Study," J. Chem. Phys. 101, 1994; 764.

Kumar Sinniah, Helen Dorsett, and Janice E. Reutt-Robey, "Chemisorption on Stepped Metal Surfaces: CO/Vicinal Ni(100)," J. Chem. Phys. 98, 1993; 9018.

Kumar Sinniah, Helen E. Dorsett, and Janice E. Reutt-Robey, "CO Mobility on Vicinal Ni(100) - Step Adsorption-Desorption Processes," Abstracts of Papers of the American Chemical Society 205, 1993; 327.

Kumar Sinniah, William D. Sands, John T. Yates, Jr., and Kenneth C. Janda, "The Rate Law and Activation Energy of Isotope Mixing between Chemisorbed CO Molecules on a K promoted Ni(111) Surface," J. Am. Chem. Soc. 113, 1991; 3684.

Kumar Sinniah, William D. Sands, Jan Hrbek, John T. Yates, Jr., and Kenneth C. Janda, "Isotope Mixing between Chemisorbed CO molecules on a K promoted Ni(111) Surface: An LITD study," Surf. Sci. Lett. 243, 1991; L67.

Kumar Sinniah, Michael G. Sherman, John T. Yates, Jr., W. Henry Weinberg, and K enneth C. Janda, "Recombinative Desorption of Hydrogen from Si(100)," Abstracts of Papers of the American Chemical Society 201, 1991; 50.

Kumar Sinniah, Michael G. Sherman, John T. Yates, Jr., and Kenneth C. Janda, "Adsorption and Decomposition of Chemisorbed Propylene on the Si(100)-(2x1) surface: A Laser -Induced Thermal Desorption Study," Proceedings of the International Society for Optical Engineering 1208, 1990; 63.

Kenneth C. Janda, Kumar Sinniah, William Sands, and John T. Yates, Jr., "Laser Studies of Kinetics on Surfaces," Abstracts of Papers of the American Chemical Society 200, (1990) 101.

Kumar Sinniah, Michael G. Sherman, Lisa B. Lewis, W. Henry Weinberg, John T. Yates, Jr., and Kenneth C. Janda, "Hydrogen Desorption from the Monohydride Phase on Si(100)," J. Chem. Phys. 92, 1990; 5700.

Kumar Sinniah, Michael G. Sherman, Lisa B. Lewis, W. Henry Weinberg, John T. Yates, Jr., and Kenneth C. Janda, "New Mechanism for Hydrogen Desorption from Covalent Surfaces: The Monohydride Phase on Si(100)," Phys. Rev. Lett. 62, 1989; 567.

Kumar Sinniah, Michael G. Sherman, John T Yates, Jr., W. Henry Weinberg, and Kenneth C. Janda, "Desorption Kinetics of H 2 from Si(100)," Abstracts of Papers of the American Chemical Society 196, 1988; 124.

Presentations (since 2001)

Laura Porter-Peden, Sarah Kamper, Kumar Sinniah, Ronald Blankespoor, Dejian Zhou, Chris Abell, and Trevor Rayment, "Kinetics and thermodynamics of enzyme-inhibitor interactions", Joint Meeting of the Biophysical Society 52 nd Annual Meeting & 16 th International Biophysics Congress, Long Beach, CA, February 2-6, 2008. (Laura Porter-Peden was a Biophysical Society Travel Award Winner)

Sarah Kamper, Laura Porter-Peden, Ronald Blankespoor, Stephanie Hoogendorn, Mark Vander Wal, and Kumar Sinniah, "The effect of tether length in single molecule force spectroscopy", Joint Meeting of the Biophysical Society 52 nd Annual Meeting & 16 th International Biophysics Congress, Long Beach, CA, February 2-6, 2008. (Sarah Kamper was a Biophysical Society Travel Award Winner)

Jennifer Nichols, Joseph Buthker, and Kumar Sinniah, "The effect of divalent cations (Mg2+ , Zn2+ , Mn2+ , and Ca2+ ) on the hybridization efficiency of DNA", Joint Meeting of the Biophysical Society 52 nd Annual Meeting & 16 th International Biophysics Congress, Long Beach, CA, February 2-6, 2008.

Sarah Kamper, Laura Porter-Peden, Kumar Sinniah, Ronald Blankespoor, Chris Abell, and Trevor Rayment, "A single molecule study of enzyme-inhibitor interactions", 233rd ACS National Meeting, Chicago, March 25-29, 2007.

Joseph Buthker, Jennifer Nichols, and Kumar Sinniah, "Determining the effects of divalent cations on DNA using AFM", 233rd ACS National Meeting, Chicago, March 25-29, 2007.

Mark Vander Wal, Sarah G. Kamper, Jennifer Headley, and Kumar Sinniah, "Factors affecting the study of biomolecular interactions", 37 th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI, May 31-June 2, 2006.

Sarah G. Kamper, Jennifer Headley, Mark Vander Wal, and Kumar Sinniah, "Is force spectroscopy an effective method for discriminating the binding of drugs to DNA?", 37 th Great Lakes Regional Meeting of the American Chemical Society, Milwaukee, WI, May 31-June 2, 2006.

Kumar Sinniah, Sarah Kamper, Laura Porter-Peden, Xiuzhu Wang, Dejian Zhou, Chris Abell, and Trevor Rayment, "Investigating enzyme inhibitor interactions by force spectroscopy", CUR 2006 National Conference, DePauw University, Indiana, June 24-27, 2006.

Sabina Thyle, Mark Schotanus, Kimberly Aumann, and Kumar Sinniah, "Investigation of drug-DNA interactions by Force Spectroscopy", The Michigan Academy of Science, Arts, and Letters 2004 Meeting, March 5, 2004.

Sabina Thyle, Mark Vander Wal, Tamar Hunse, Mark Schotanus, Kimberly Aumann, and Kumar Sinniah, "Investigating drug-DNA interactions by force spectroscopy", Council on Undergraduate Research, 10 th National Conference, June 23-26, 2004.

Eric Arnoys, Carissa Hockema, and Kumar Sinniah, "Visualization of F-Actin by Scanning Probe Microscopy", 33 rd Great Lakes ACS Central Regional Meeting, June 11-13, 2001.

Kumar Sinniah, Joel Visser, and Karen Gilliland, "Analysis of volatile organics from a painting studio", 33 rd Great Lakes ACS Central Regional Meeting, June 11-13, 2001.

Julia Heetderks, Kumar Sinniah, Melvin Schindler, and Marcos Dantus, "Investigations of Streptavidin-Biotin binding by Atomic Force Microscopy", 33rd Great Lakes ACS Central Regional Meeting, June 11-13, 2001.

Kumar Sinniah, Jamie Paauw, and John Ubels, "Use of Atomic Force Microscopy to observe cells in culture", 33rd Great Lakes ACS Central Regional Meeting, June 11-13, 2001.

Kimberly Aumann, Kumar Sinniah, and Elizabeth Howell, "DNA binding of replication factor C and proliferating cell nuclear antigen as imaged using atomic force microscopy", 33rd Great Lakes ACS Central Regional Meeting, June 11-13, 2001.

Minors

Minor in Biochemistry

Minor in Chemistry

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