Publications with students since 1997

Hoffman HM, Choi JH, Clousing DP, Ubels JL, McCarey BE, Edelhauser HF. Corneal epithelial testing strategies for safety evaluation of ophthalmic formulations. Cutaneous and Ocular Toxicology. (in press)

Ubels JL, Hoffman HM, Srikanth S, Resau JH, Webb CP. Gene expression in rat lacrimal gland duct cells collected using laser capture microdissection: evidence for K+ secretion by duct cells. Investigative Ophthalmology and Visual Science. 47:1876-1885, 2006.

Ubels JL, Clousing DP. In vitro alternatives to the use of animals in ocular toxicology. The Ocular Surface. 3:126-142, 2005.

Ubels JL, Ditlev JA, Clousing DP, Casterton PL. Corneal permeability in a redesigned corneal holder for the bovine cornea opacity and permeability assay. Toxicology in Vitro. 18:853-857, 2004.

Ubels JL, Clousing DP, Van Haitsma TA, Hong BS, Stauffer P, Asgharian B, Meadows D. Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent. Current Eye Research. 28:437-444, 2004.

Ubels JL, Veenstra E, Ditlev J, Ingersoll K. Interactions of testosterone and all-trans retinoic acid in regulation of androgen receptor expression in rat lacrimal gland. Experimental Eye Research. 77:741-748, 2003.

Ubels JL, Paauw JD, Casterton PL. Evaluation and refinement of the bovine cornea opacity and permeability assay. In: Alternative Toxicologic Methods, Katz S, Salem H (eds) CRC Press LCC, Boca Raton, FL. 107-113, 2003.

Ubels JL, Aupperlee MD, Meadows DL. Artificial tear solutions and protection of the corneal epithelium from desiccation. Cutaneous and Ocular Toxicology 21:273-281, 2002.

Ubels JL, Aupperlee MD, Jackson RS, Van Dyken SJ, McCartney MD. Topically applied 15-(S)-HETE stimulates mucin production by corneal epithelium. Advances in Experimental Medicine and Biology. 605:317-321, 2002.

 Auperlee MD, Wertz JT, Ingersoll KE, Ubels JL. Identification of androgen receptors in rabbit lacrimal gland. Advances in Experimental Medicine and Biology. 506:137-141, 2002.

Sinniah K, Paauw JD, Ubels JL. Investigating live and fixed epithelial cells by atomic force microscopy. Current Eye Research. 25:61-68, 2002.

Ubels JL, Paauw JD, Casterton PL, Kool DJ. A redesigned corneal holder for the bovine cornea opacity and permeability assay that maintains normal corneal morphology. Toxicology in Vitro. 16:621-628, 2002.

Ubels JL, Wertz JT, Ingersoll KE, Jackson RS, Aupperlee MD. Down-regulation of androgen receptor expression and inhibition of lacrimal gland cell proliferation by retinoic acid. Experimental Eye Research. 75:561-571, 2002.

Jackson RS, Van Dyken SJ, McCartney MD, Ubels JL. The eicosanoid, 15-(S)-HETE, stimulates secretion of a mucin-like glycoprotein by the corneal epithelium, Cornea. 20:516-521, 2001.

Ubels JL, Pruis RM, Sybesma JT, Casterton PL. Corneal opacity, hydration and endothelial morphology in the bovine cornea opacity and permeability assay using reduced treatment times. Toxicology in Vitro. 14:379-386, 2000.

Saarloos MN, Husa M, Jackson RS, Ubels JL. Intermediate filament, laminin, and integrin expression in lacrimal gland acinar cells; comparison of an immortalized cell line to primary cells and their response to retinoic acid. Current Eye Research. 19:439-449, 1999.

Ubels JL, Erickson AM, Zylstra U, Kruelen CD, Casterton PL. The effect of corneal hydration on opacity in the bovine cornea opacity and permeability assay. Cutaneous and Ocular Toxicology. 17:197-220, 1998.

Ubels JL, Woo EM, Curley RW. N-linked glycoside and glucuronide conjugates of the retinoid, acitretin, are biologically active in cornea and conjunctiva. Journal of Ocular Pharmacology and Therapeutics. 17:197-220, 1998.

Ubels JL, Woo EM, Watts WJ, Smith LK, Zylstra U, Beaird J, McCartney MD. Conjunctival permeability and ultrastructure: Effects of benzalkonium chloride and artificial tears. Advances in Experimental Medicine and Biology. 438:723-730, 1998.

Bossenbroek NM, Sulahian TH, Ubels JL. Expression of retinoic acid receptors and retinoid X receptors in the cornea and conjunctiva. Current Eye Research. 17:462-469, 1998.

Ubels JL, Sulahian TS, Viel MD. The lacrimal gland expresses retinoid X receptors. Current Eye Research. 16:511-515, 1997.