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John Ubels' selected publications

Stoddard AR, Koetje LR, Mitchell AK, Schotanus MP, Ubels, JL. Bioavailability of antioxidants applied to stratified human corneal epithelial cells. Journal of Ocular Pharmacology Therapy. DOI: 10.1089/jop.2013.0014.

Ubels, John L, Schotanus, Mark P, Bardolph, Susan L, Haarsma, Loren D, Koetje, Leah R, Louters, Julienne R. Inhibition of UV-B induced apoptosis in corneal epithelial cells by potassium channel modulators. Experimental Eye Research 90:216-222, 2010.

Ubels John L, Van Dyken Rachel E, Louters Julienne R, Schotanus Mark P, Haarsma Loren D. Potassium ion fluxes in corneal epithelial cells exposed to UVB. Experimental Eye Research. 92:425-431, 2011.

Konynenbelt, Benjamin J, Mlnarik, Daniel S, Ubels, John L. Effects of peroxide based contact lens disinfecting systems on human corneal epithelial cells in vitro. Eye and Contact Lens. 37:286-297, 2011.

Schotanus MP, Koetje LR, Van Dyken RE, Ubels JL. Stratified corneal limbal epithelial cells are protected from UVB-induced apoptosis by elevated extracellular K+. Experimental Eye Research. 93:735-740, 2011.

Ubels JL, Van Dyken R, Louters JR, Schotanus MP, Haarsma LD. Potassium ion fluxes in corneal epithelial cells exposed to UVB. Experimental Eye Research 92:425-431, 2011

Konynenbelt BJ, Mlnarik DS, Ubels JL. Effects of peroxide based contact lens disinfecting systems on human corneal epithelial cells in vitro. Eye and Contact Lens doi: 10.1097/ICL.0b013e3182182d02, 2011

Ubels JL, Schotanus MP, Bardolph SL, Haarsma LD, Koetje LR, Louters JR. Inhibition of UV-B induced apoptosis in corneal epithelial cells by potassium channel modulators. Exp Eye Res 90:216-222, 2010.

Lim ML, Hurst RK, Konynenbelt BJ, Ubels JL. Cytotoxicity testing of multipurpose contact lens solutions using monolayer and stratified cultures of human corneal epithelial cells. Eye and Contact Lens 35:287-296, 2009.

Singleton KR, Will DS, Schotanus MP, Haarsma, LD; Koetje LR, Bardolph SL, Ubels JL. Elevated Extracellular Potassium Inhibits Apoptosis of Corneal Epithelial Cells Exposed to UV-B Radiation. Experimental Eye Research 89:140-151, 2009.

Shaffer HE, Ubels JL. Use of laser capture microdissection and cDNA microarrays for analysis of gene expression in lacrimal gland secretory cells of MRL/lpr mice. Journal of Young Investigators. Volume 19, November 2008 http://www.jyi.org/research/re.php?id=1664

Hoffman HM, Choi JH, Clousing DP, Ubels JL, McCarey BE, Edelhauser HF. Corneal epithelial testing strategies for safety evaluation of ophthalmic formulations. Cutaneous and Ocular Toxicology 26:311-327, 2007.

Ubels JL, Hoffman HM, Srikanth S, Resau JH, Webb CP. Gene expression in rat lacrimal gland duct cells collected using laser capture microdissection: evidence for K+ secretion by duct cells. Investigative Ophthalmology and Visual Science. 47:1876-1885, 2006.

Ubels JL, Clousing DP. In vitro alternatives to the use of animals in ocular toxicology. The Ocular Surface. 3:126-142, 2005.

Ubels JL, Ditlev JA, Clousing DP, Casterton PL. Corneal permeability in a redesigned corneal holder for the bovine cornea opacity and permeability assay. Toxicology in Vitro.18:853-857, 2004.

Ubels JL, Clousing DP, Van Haitsma TA, Hong BS, Stauffer P, Asgharian B, Meadows D. Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent. Current Eye Research. 28:437-444, 2004.

Ubels JL, Veenstra E, Ditlev J, Ingersoll K. Interactions of testosterone and all-trans retinoic acid in regulation of androgen receptor expression in rat lacrimal gland. Experimental Eye Research. 77:741-748, 2003.

Ubels JL, Paauw JD, Casterton PL. Evaluation and refinement of the bovine cornea opacity and permeability assay. In: Alternative Toxicologic Methods, Katz S, Salem H (eds) CRC Press LCC, Boca Raton, FL. 107-113, 2003.

Ubels JL, Aupperlee MD, Meadows DL. Artificial tear solutions and protection of the corneal epithelium from desiccation. Cutaneous and Ocular Toxicology 21:273-281, 2002.

Ubels JL, Aupperlee MD, Jackson RS, Van Dyken SJ, McCartney MD. Topically applied 15-(S)-HETE stimulates mucin production by corneal epithelium. Advances in Experimental Medicine and Biology. 605:317-321, 2002.

 Auperlee MD, Wertz JT, Ingersoll KE, Ubels JL. Identification of androgen receptors in rabbit lacrimal gland. Advances in Experimental Medicine and Biology. 506:137-141, 2002.

Sinniah K, Paauw JD, Ubels JL. Investigating live and fixed epithelial cells by atomic force microscopy. Current Eye Research. 25:61-68, 2002.

Ubels JL, Paauw JD, Casterton PL, Kool DJ. A redesigned corneal holder for the bovine cornea opacity and permeability assay that maintains normal corneal morphology. Toxicology in Vitro. 16:621-628, 2002.

Ubels JL, Wertz JT, Ingersoll KE, Jackson RS, Aupperlee MD. Down-regulation of androgen receptor expression and inhibition of lacrimal gland cell proliferation by retinoic acid. Experimental Eye Research. 75:561-571, 2002.

Jackson RS, Van Dyken SJ, McCartney MD, Ubels JL. The eicosanoid, 15-(S)-HETE, stimulates secretion of a mucin-like glycoprotein by the corneal epithelium, Cornea. 20:516-521, 2001.

Ubels JL, Pruis RM, Sybesma JT, Casterton PL. Corneal opacity, hydration and endothelial morphology in the bovine cornea opacity and permeability assay using reduced treatment times. Toxicology in Vitro. 14:379-386, 2000.

Saarloos MN, Husa M, Jackson RS, Ubels JL. Intermediate filament, laminin, and integrin expression in lacrimal gland acinar cells; comparison of an immortalized cell line to primary cells and their response to retinoic acid. Current Eye Research. 19:439-449, 1999.

Ubels JL, Erickson AM, Zylstra U, Kruelen CD, Casterton PL. The effect of corneal hydration on opacity in the bovine cornea opacity and permeability assay. Cutaneous and Ocular Toxicology. 17:197-220, 1998.

Ubels JL, Woo EM, Curley RW. N-linked glycoside and glucuronide conjugates of the retinoid, acitretin, are biologically active in cornea and conjunctiva. Journal of Ocular Pharmacology and Therapeutics. 17:197-220, 1998.

Ubels JL, Woo EM, Watts WJ, Smith LK, Zylstra U, Beaird J, McCartney MD. Conjunctival permeability and ultrastructure: Effects of benzalkonium chloride and artificial tears. Advances in Experimental Medicine and Biology. 438:723-730, 1998.

Bossenbroek NM, Sulahian TH, Ubels JL. Expression of retinoic acid receptors and retinoid X receptors in the cornea and conjunctiva. Current Eye Research. 17:462-469, 1998.

Ubels JL, Sulahian TS, Viel MD. The lacrimal gland expresses retinoid X receptors. Current Eye Research. 16:511-515, 1997.

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